Oxygen Saturation Monitoring in Bronchiolitis

PIRN is conducting a Randomized Controlled Trial (RCT) across six hospitals around the best way to monitor infants hospitalized with bronchiolitis, the most common lung infection and a leading reason for hospitalization in infants. Infants with bronchiolitis have breathing difficulties and are provided supplemental oxygen if their oxygen levels are low. However, it is not known how to best monitor oxygen levels. A probe placed on the hand or foot can be used to monitor oxygen levels all the time (continuous oxygen monitoring) or just every 4-6 hours (intermittent oxygen monitoring). The objective of this study is to conduct high quality research across hospitals to determine whether intermittent compared to continuous oxygen monitoring will reduce the length of hospital stay in infants hospitalized with bronchiolitis. The investigators will also compare safety and cost. The results of this study will inform bronchiolitis practice standards and the best use of health care resources Click here to read the study protocol published in BMJ Open.

Funding source: Canadian Institutes of Health Research (CIHR)

Bronchiolitis Implementation Science Study

PIRN is conducting an Implementation Science study across six sites in collaboration with the St. Michaels KT Program to understand the practice of bronchiolitis oxygen saturation monitoring for hospitalized children. We are completing a qualitative study to understand why clinicians use and/or don’t use intermittent (e.g. every 4-6 hours) or continuous oxygen saturation monitoring in stable hospitalized infants with bronchiolitis by interviewing clinicians (nurses, respiratory therapists, physicians and hospital leaders) as well as parents. Implementation Science is a scientific inquiry to understand what, why and how interventions, programs or policies work and how best to improve their implementation. The results of the study will inform hospital policies and practice guidelines to support the use of intermittent monitoring and reduce the practice gap for bronchiolitis care in paediatric hospital care. 

Funding source: Paediatric Consultants Partnership's Grants For Creative Professional Activity

Care and outcomes of Canadian children hospitalized with periorbital and orbital cellulitis 

Periorbital cellulitis is an infection of the tissues surrounding the eye while orbital cellulitis is an infection of the tissues within the eye socket. These two infections are often considered together as they can be hard to differentiate. Children present with swelling and redness of the eye, and in severe cases, can have pain with eye movements, reduced vision and a bulging eye. Complications of these infections include loss of vision, brain infection and death. Most children with periorbital cellulitis can be treated with oral antibiotics at home while children with orbital cellulitis need to be admitted to hospital, treated with intravenous antibiotics and potentially need surgery. There are several important unanswered research questions relating to how hospitalized children with these infections are managed, such as which antibiotics to use, and which children need a CT scan. PIRN is conducting a retrospective study across 10 hospitals to determine how care for Canadian children can be improved. Click here to read the study protocol published in BMJ Open.

Paediatric Hospital Care Priority Setting Study

PIRN is working with the James Lind Alliance (JLA) in a Priority Setting Partnership (PSP) to identify the Top 10 research questions  for Inpatient General Paediatrics in Canada.


This Partnership aims to shape the future research agenda for PIRN and paediatric hospital care by bringing together clinicians, patients and caregivers to identify and prioritize unanswered questions around treatment and care. This study is being funded by a CIHR Catalyst Grant in Patient Oriented Research. Click here to learn more

Funding source: Canadian Institutes of Health Research (CIHR)